"Nobel Prize-Worthy Discovery May Safeguard
Your Heart and Blood Vessels*"

It's a simple little amino acid, but it does a big job in keeping your blood freely moving throughout your body by keeping your blood vessels dilated and flexible.* Yet hardly anyone knows about this amazing discovery. Do you?

Since 1901, a Nobel Prize in Physiology or Medicine has been awarded every year (with few exceptions) to brilliant men and women around the world.

Many recipients of this prestigious honor for outstanding achievement spent decades conducting complex laboratory and clinical research.

Over the years, Nobel Prizes for medical achievements have been awarded for extraordinary discoveries from…

  • Insulin (1923) to …
  • Vitamin K identification (1943) to…
  • Penicillin (1945) to…
  • Heart catherization (1956) to…
  • Magnetic Resonance Imagery (MRI) technology (2003)…

…Just to name a very few…

One of most significant, yet little understood discoveries ever awarded by the Nobel Assembly (Swedish awarding body), occurred in 1998.

The 1998 Nobel Prize in Medicine recognized a 3-man research team for their identification of "nitric oxide as a signaling molecule in the cardiovascular system."

Doesn't sound real significant… but I assure you it was.

To put into perspective the importance of the 1998 Nobel Prize in Medicine, we need to first take a closer look…

At the Heart of YOUR Matter

L-arganine supports endothelial function to a healthy cardiovascular system.
"For optimal health, the vital components of your cardiovascular system need to work together efficiently… your: heart, blood, arteries, veins, and capillaries."

By far, one of the most important systems in your entire body is your cardiovascular system.

Every year, millions of people around the world experience less-than-optimal cardiovascular health… and this is by no means restricted just to the male population.

According to the American Heart Association (AHA), many people across all age groups experience less-than-optimal cardiovascular health.

It pretty much goes without saying how important it is to keep your entire cardiovascular system working as efficiently as possible.

You probably know from your academic days studying biology, blood flow is key to your cardiovascular system… it's the 'nutritious oil' that feeds all your vital organs and keeps everything running smoothly.

What happens if your blood flows less-than-optimally?

Well, it may keep your heart and other organs from functioning at their best.

But what helps keep blood flowing optimally… what keeps your blood vessels relaxed and elastic to best support your system?

Some of the answers to this directly correlate to the 1998 Nobel Prize in Medicine… and to an essential amino acid involved in multiple areas of human physiology and metabolism.


How an Air Pollutant Gas Helps Your Blood Vessels Relax

The 1998 Nobel Prize in Medicine recipients discovered a remarkable way your blood vessels do everything possible to stay dilated (open) for optimal blood flow.…

But no one really knew how extensive a role nitrogen played prior to the discoveries leading to the 1998 Nobel Prize.

L-arganine may help support endothelial vascular function
The 1998 Nobel Prize winners discovered how endothelial cells produce nitric oxide to help blood vessels stay relaxed and open for blood flow.

What Furchgott, Murid, and Ignarro researched and discovered was how

  • Vasodilating (vessel widening) compounds release a gas to help relax muscle cells in your veins
  • Endothelial cells lining your blood vessels produce this gas to help support healthy blood flow*
  • Nitric oxide is the gas released as a cellular signaling molecule to help promote healthy blood vessel flexibility and dilation*

What further made this discovery particularly surprising is nitric oxide is also a common air pollutant formed when nitrogen burns – like in automobile exhaust fumes.

The use of a gas, in this case nitric oxide for signaling between cells in your body, is an entirely new concept with far-reaching potential scientific and health benefits now and in the future.

Nitric oxide

  • Enhances your blood flow when produced by blood vessel cells*
  • Helps support healthy blood pressure levels that are already within the normal range*
  • Is used as a signal molecule in your brain and immune system*

Coming up, I’ll get into more on what happens to this vital nitric oxide signaling process as you age… and the essential amino acid needed to produce it that you could be falling short in.

But first, let's take a short trip back in time to learn how Alfred Nobel may have played an unknown role in this amazing discovery.

Nobel Prize Founder and Nitric Oxide

In addition to creating the Nobel Prizes, Alfred Nobel also invented dynamite – an explosive produced by a nitrogen-based compound and diatomaceous earth.

At one point in Nobel's life, his doctor ironically suggested a compound that signals nitric oxide release in order to support his heart health. Nobel refused to take it.

Back in the late 1800s, there must have been an inkling of the value of products that trigger the release of nitric oxide gas.

But it would take close to 100 years until it was fully identified how such products act by releasing nitric oxide gas as a signal molecule… little did Alfred Nobel know at the time of his doctor's recommendation.

What Happens to Your Blood Vessels as You Age?

Nitric oxide promotes optimal blood flow and cardiovascular health.
As your efficiency to produce nitric oxide slows down with normal aging, your body could use some help to support optimal blood flow.

At this point, you should start to see the importance of the nitric oxide discovery.

But, what happens to nitric oxide production as you get older?

Quite simply, just like other bodily functions, nitric oxide signaling efficiency declines as a normal part of aging.

Remember, your endothelial cells produce nitric oxide to help your vessels stay relaxed and open for blood flow.

As your efficiency to produce nitric oxide slows down, your body could use some help to support optimal blood flow.*

Knowing how nitric oxide works and its effects on your blood vessel efficiency is critically important information for your health and science.

And remember how I mentioned earlier how millions of people around the world could likely benefit from taking a supplement to support cardiovascular health?

Certainly, the nitric oxide discovery could potentially play a significant role in helping provide this support.*

But how?

How Nitric Oxide Is Efficiently Produced by Your Blood Vessels

Clinical research gives us a clue as to what's needed to efficiently produce nitric oxide in your vessels.

A semi-essential amino acid called L-arginine appears to be at the heart of the matter.

L-arginine is…

  • A precursor to nitric oxide
  • Needed by the lining in your vessels (endothelium) to create nitric oxide *
  • The only known nutritional substrate in your vessel lining available to endothelial cells for nitric oxide production*

Here are just a few examples of the research conducted to evaluate L-arginine's potential…

  • 2005: Rainer H. Boger, MD, and Eval S. Ron, PhD

Purpose: Evaluated endothelial function and supportive affects of L-arginine
Conclusions/Results: Sustained-release L-arginine promotes improvement and helps support endothelial vascular function.*

  • 2000: Alfonso Siani et al

Purpose: Evaluated blood pressure and metabolic changes during L-arginine supplementation in humans
Conclusions/Results: Found indication of a moderate increase in L-arginine could promote healthy blood pressure levels that are already within the normal range in healthy people.*

  • Journal of Nutrition American Society for Nutritional Sciences (2004) Heather L. Gornik and Mark A. Creager

Purpose: Evaluated and reviewed L-arginine applications in various research and clinical trials
Conclusions/Results: In many animal and human models, L-arginine improves endothelial function and promotes a healthy cardiovascular system.*

The take-away from the research is L-arginine is a key nutrient in promoting efficient blood flow and supporting your healthy cardiovascular system.*

Plus, recent research suggests that L-arginine can potentially support your immune system by promoting a healthy immune response.*

But what exactly is L-arginine and how do you ensure your body produces the optimal amounts?

How to Avoid L-arginine Deficiencies

As I mentioned above, L-arginine is an amino acid functioning as a building block of proteins.

Your body produces L-arginine and it plays a significant role in multiple areas of your physiology and metabolism because it...*

  • Significantly affects your cardiovascular system… in particular, your blood vessel vitality*
  • Plays a critical role in maintaining the natural, healthy functions of your vascular endothelium (vessel lining)*
  • Promotes blood vessel relaxation and flexibility from the nitric oxide created by your vascular endothelium*

Without enough L-arginine, your endothelial cells may not create enough nitric oxide to promote optimal blood flow and cardiovascular health.* And as far as your immune system, not having enough L-arginine could desensitize important white cell components called neutrophils… vital in a healthy immune system response.*

What could cause L-arginine deficiencies in your system?


  • Might not consume and digest enough protein
  • Could require more L-arginine in your system due to inherited genetics
  • May be prone to lower levels of antioxidants and excessive free radicals

Making sure you get enough protein in your system and eating the right natural foods to increase antioxidant nutrients can help.

But like most everything else, as a normal part of aging, your bodily functions just seem to slow down and become less efficient.

Since L-arginine is available as a supplement today, the answer seems quite simple on how to enhance your body supply… but unfortunately it is not.

Why Controlling Absorption Rate Is Key

Just like other supplemental nutrients in the marketplace today, L-arginine formulas vary widely.

And one of the biggest challenges with L-arginine is its absorption rate.

Your body very rapidly absorbs and metabolizes L-arginine. This means you would likely have to take supplements frequently during the day in order to maintain increased levels of L-arginine in your body.

You can rest assured this is not an acceptable solution for me… and likely is not for you as well.

What I did discover is an L-arginine solution with a unique patented formula for what's called 'sustained-release.'

Sustained-release helps you maintain an optimal level of L-arginine in your system over a 24 hour period… reducing the need to frequently take capsules throughout the day.*

I’d like to introduce to you the only formula my team could find with this unique sustained-release solution –L-Arginine.

And I didn't stop here… I wasn't about to settle for just any manufacturer of L-arginine.


How You Can Avoid Synthetic L-arginine Formulas

As important as the sustained release formula was for my recommendation of L-Arginine, I also made sure the manufacturer used good manufacturing processes for pure natural production of L-arginine as well.

L-Arginine is unique because the chosen manufacturer…

  • Uses only natural, pure powdered ingredients in the L-arginine formula
  • Avoids artificial fillers and additives
  • Never uses fatty acid excipients to help process flow – avoids ingredients that I believe are risky such as magnesium stearate and steric acid
  • Delivers a hypoallergenic formula – great care taken in process and formulation to minimize potential allergens*
  • Blends in unique patented ingredient for sustained-release of L-arginine nutrient – no need to frequently take doses during the day to maintain optimal levels in your system*

This provides further evidence why I strongly recommend L-Arginine as your source of L-arginine with the added benefit of sustained-release.

And here's a summary of the…

8 Reasons This Formula Is at the Top of My List

L-Arginine - Cardiovascular Support*

Let me quickly summarize your potential benefits from L-Arginine*

  • Helps blood vessels relax to promote optimal blood flow in your body*
  • Aids in helping to maintain healthy blood pressure levels that are already within the normal range*
  • Promotes healthy breathing*
  • Provides vital support for your immune system*
  • Helps support skin health*
  • Enhances your exercise tolerance*
  • Supports healthy kidney function*
  • Promotes your overall cardiovascular system vitality*

These powerful benefits should leave you little doubt about the potential boost and protection to your cardiovascular system and overall health.

And when you add the fact I carefully selected a high-quality formula produced by a very reputable and health-conscious manufacturer… L-Arginine is an extraordinary winning combination.

The Perfect Trifecta for Your Cardio Health

Cardio Support Pack
My Cardiac Support Pack offers extra support for your heart health

I think by now you know how valuable L-Arginine can potentially be for your health. Is there even more you could do to support your heart health?

A resounding “yes!”

If you’re not already getting a wholesome animal source of omega-3 fatty acids and taking a high-quality CoQ10 or Ubiquinol, then my Cardiac Support Pack may be the ideal choice to give you an extra edge of support.

My Antarctic Krill Oil offers unparalleled support for your heart, brain, and total body health with its bountiful and bioavailable omega-3 fatty acids.* Dramatically different from those in fish oils, krill oil’s omega-3s – DHA and EPA – are transported in liposome form for easy and fast delivery to your cells.

Ubiquinol, the reduced, active form of CoQ10 (ideal for those over 30) helps guard against cellular and mitochondrial damage to help ensure your heart, brain, muscles and other fuel-hungry tissues receive the energy they need for their healthy function.*

My Cardiac Support Pack includes all three supplements – L-Arginine, Krill Oil, and Ubiquinol in one convenient pack to help you save time and money!

Take This Message to Heart Today

Hopefully by now, you have a better understanding of the importance of the 1998 Nobel Prize in Medicine.

The discovery of how nitric oxide gas transmits signals within your cardiovascular system was truly remarkable.

And with research identifying how vital L-arginine can be in creating nitric oxide, it's reassuring to know there's a potential way for you to enhance nitric oxide production.*

Keep in mind that as you age, your vascular system's ability to produce L-arginine for effective nitric oxide production naturally declines.

With L-Arginine and its sustained-release nutrient, your vessel lining can get the potential L-arginine boost you desire.*

Any way to efficiently enhance and maintain your healthy blood flow only helps promote the overall health of your cardiovascular system and other bodily functions as well.*

That’s why I strongly recommend L-Arginine and my Cardiac Support Pack.

Give your cardiovascular system the boost and protection you desire and order L-Arginine today.* For extra support, order my Cardiac Support Pack with L-Arginine, Antarctic Krill Oil and Ubiquinol all in one handy pack!

Also please remember my Money Back Guarantee (see details below). Order now to give your heart the attention it deserves.*

P.S. - If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.

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If you suffer with herpes you will not want to take this supplement when you are having a flare-up as it can impair your body's ability to utilize lysine which is another important amino acid that is used to combat herpes infections.

Individuals on prescription anti-coagulant medication or anti-hypertensive drugs should consult a physician before taking L-Arginine and should be supervised by a qualified health care practitioner.

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Frequently Asked QuestionsFrequently Asked Questions
Top 5 Frequently Asked Questions
  1. 1. Q: What are the advantages of Dr. Mercola's L-Arginine?

    A: Unfortunately, many manufacturers cut corners on quality when it comes to raw ingredients to save on costs.

    In addition to the advantages of our patented sustained release L-Arginine, we use only natural, pure powered ingredients in our formula, as opposed to many synthetic formulas found on the market today.

    We use no artificial fillers or additives in our formula, and avoid the use of questionable ingredients, such as magnesium stearate and steric acid.

    With Mercola L-Arginine, you get a high-quality formula produced by our carefully selected reputable and health-conscious manufacturer.

  2. 2. Q: Why is “Timed-Release” so important for an L-Arginine supplement?

    A: Your body rapidly absorbs and metabolizes L-Arginine, so the sustained release technology makes it so you don't need to take frequent doses to maintain optimal levels in your system.

    We use a unique patented time-release matrix, Time-Sorb®, for a controlled and steady release of L-Arginine.

  3. 3. Q: Why do I need to take four tablets a day?

    A: Two capsules twice a day, or a total of four capsules daily, provides a total of 2,000 mg of L-Arginine.

    Thanks to our sustained release, you only need to take L-Arginine twice a day.

  4. 4. Q: Can I take L-Arginine with vitamin K2?

    A: Yes, you can take both together. Neither will hinder the other.

  5. 5. Q: Are there any medications that L-Arginine shouldn't be used with?

    A: L-Arginine may have unpredictable effects on insulin, cholesterol-lowering, and estradiol medications, including birth control pills.

    L-Arginine may also increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside medications.

    Additionally, if you are taking a prescription anti-coagulant medication or anti-hypertensive drug, be sure to consult with your health care provider before taking L-Arginine.